Department of Neurobiology

Publications

NCBI bibliography

2021

Emperador-Melero J, Wong MY, Wang SSH, De Nola G, Kirchhausen T, and Kaeser PS. PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure. Nature Communications. 2021 May 24. doi: 10.1038/s41467-021-23116-w. PDF

Liu C, Goel P, Kaeser PS. Spatial and temporal scales of dopamine transmission. Nat Rev Neurosci. 2021 Apr 9. doi: 10.1038/s41583-021-00455-7. Online ahead of print. PMID: 33837376. PDF

Emperador-Melero J, De Nola G, and Kaeser PS. Intact synapse structure and function after combined knockout of PTPδ, PTPσ and LAR. Elife. 2021 Mar 3;10:e66638. doi: 10.7554/eLife.66638. PDF

Banerjee A, Imig C, Balakrishnan K, Kershberg L, Lipstein N, Uronen R-L, Wang J, Cai X, Benseler F, Rhee JS, Cooper BH, Liu C, Wojcik SM, Brose N, Kaeser PS. Molecular and functional architecture of striatal dopamine release sites. Preprint available at BioRxiv 2020.11.25.398255. PDF

 

2020

Held RG, Liu C, Ma K, Ramsey AM, Tarr TB, De Nola G, Wang SSH, Wang J, van den Maagdenburg AMJM, Schneider T, Sun J, Blanpied TA, Kaeser PS. Synapse and active zone assembly in the absence of presynaptic Ca2+ channels and Ca2+ entry. Neuron 2020, Aug 19;107(4):667-683.e9. doi: 10.1016/j.neuron.2020.05.032. Epub 2020 Jun 16. PMID: 32616470. PDF

Nyitrai H, Wang SSH, Kaeser PS. ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals. Cell Rep 2020 Jun 9;31(10):107712. doi: 10.1016/j.celrep.2020.107712. PMID: 32521280. PDF

Banerjee A, Lee J, Nemcova P, Liu C, Kaeser PS. Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release. Elife 2020 Jun 3;9:e58359. doi: 10.7554/eLife.58359. Online ahead of print. PMID: 32490813. PDF

Emperador-Melero J, Kaeser PS. Assembly of the presynaptic active zone. Curr Opin Neurobiol 2020 May 11;63:95-103. doi: 10.1016/j.conb.2020.03.008. Online ahead of print. PMID: 32403081. PDF

Luo L, Ambrozkiewicz MC, Benseler F, Chen C, Dumontier E, Falkner S, Furlanis E, Gomez AM, Hoshina N, Huang WH, Hutchison MA, Itoh-Maruoka Y, Lavery LA, Li W, Maruo T, Motohashi J, Pai EL, Pelkey KA, Pereira A, Philips T, Sinclair JL, Stogsdill JA, Traunmüller L, Wang J, Wortel J, You W, Abumaria N, Beier KT, Brose N, Burgess HA, Cepko CL, Cloutier JF, Eroglu C, Goebbels S, Kaeser PS, Kay JN, Lu W, Luo L, Mandai K, McBain CJ, Nave KA, Prado MAM, Prado VF, Rothstein J, Rubenstein JLR, Saher G, Sakimura K, Sanes JR, Scheiffele P, Takai Y, Umemori H, Verhage M, Yuzaki M, Zoghbi HY, Kawabe H, Craig AM. Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. Neuron. 2020 Apr 8;106(1):37-65.e5. doi: 10.1016/j.neuron.2020.01.008. PDF

 

2019

Liu C, Kaeser PS. Nanoscale Location Matters: Emerging Principles of Ca2+ Channel Organization at the Presynaptic Active Zone. Neuron. 2019 Nov 20;104(4):627-629. doi:10.1016/j.neuron.2019.10.015. PDF

Persoon CM, Hoogstraaten RI, Nassal JP, van Weering JRT, Kaeser PS, Toonen RF, Verhage M. The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators. Neuron. 2019 Oct 11. pii: S0896-6273(19)30788-3. doi: 10.1016/j.neuron.2019.09.015. PDF

Tyssowski KM, Letai KC, Rendall SD, Tan C, Nizhnik A, Kaeser PS, Gray JM. Firing rate homeostasis can occur in the absence of neuronal activity-regulated transcription. J Neurosci. 2019 Oct 31. pii: 1108-19. doi: 10.1523/JNEUROSCI.1108-19.2019. PDF

Robinson BG, Cai X, Wang J, Bunzow JR, Williams JT, Kaeser PS. RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain. Elife. 2019 Sep 5;8. pii: e47972. doi: 10.7554/eLife.47972. PMID: 31486769. PDF

Saka SK, Wang Y, Kishi JY, Zhu A, Zeng Y, Xie W, Kirli K, Yapp C, Cicconet M, Beliveau BJ, Lapan SW, Yin S, Lin M, Boyden ES, Kaeser PS, Pihan G, Church GM, Yin P. Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues. Nat Biotechnol. 2019 Sep;37(9):1080-1090. PMID: 31427819. PDF

Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Cornelisse LN, Farrell RJ, Goldschmidt HL, Howrigan DP, Hussain NK, Imig C, de Jong APH, Jung H, Kohansalnodehi M, Kramarz B, Lipstein N, Lovering RC, MacGillavry H, Mariano V, Mi H, Ninov M, Osumi-Sutherland D, Pielot R, Smalla KH, Tang H, Tashman K, Toonen RFG, Verpelli C, Reig-Viader R, Watanabe K, van Weering J, Achsel T, Ashrafi G, Asi N, Brown TC, De Camilli P, Feuermann M, Foulger RE, Gaudet P, Joglekar A, Kanellopoulos A, Malenka R, Nicoll RA, Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, Tilgner HU, Bagni C, Bayés À, Biederer T, Brose N, Chua JJE, Dieterich DC, Gundelfinger ED, Hoogenraad C, Huganir RL, Jahn R, Kaeser PS, Kim E, Kreutz MR, McPherson PS, Neale BM, O'Connor V, Posthuma D, Ryan TA, Sala C, Feng G, Hyman SE, Thomas PD, Smit AB, Verhage M. SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron. 2019 Jul 17;103(2):217-234.e4. PDF

Emperador-Melero J, Kaeser PS. Liquid Active Zones for Controlling the Phases of Synaptic Transmission. Mol Cell. 2019 Mar 7;73(5):859-860. PDF

Liu C, Kaeser PS. Mechanisms and regulation of dopamine release. Current Opinion in Neurobiology. 2019 Aug;57:46-53. PDF

 

2018

Wang SSH, Kaeser PS. A Presynaptic Liquid Phase Unlocks the Vesicle Cluster. Trends Neurosci. 2018 Nov;41(11):772-774. PDF

deJong APH, Roggero CM, Ho MR, Wong MY, Brautigam CA, Rizo J, Kaeser PS. RIM C2B domains target presynaptic active zone functions to PIP2-containing membranes. Neuron. 2018 Apr 18;98(2):335-349.e7. doi: 10.1016/j.neuron.2018.03.011. Epub 2018 Mar 29. PMID: 29606581 PDF

Held RH, Kaeser PS. ELKS active zone proteins as multitasking scaffolds for secretion. Open Biol. 2018 Feb;8(2). pii: 170258. doi: 10.1098/rsob.170258. Review. PMID: 29491150 PDF

Wong MY, Liu C, Wang SH, Roquas A, Fowler S, Kaeser PS. Liprin-alpha3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses. PNAS. 2018 Feb 27;115(9):2234-2239. doi: 10.1073/pnas.1719012115. Epub 2018 Feb 8. PMID: 29439199. PDF

Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser PS. Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites. Cell. 2018 Feb 8;172(4):706-718.e15. PDF

 

2017 

Biederer TB, Kaeser PS, Blanpied TA: Transcellular nanoscale alignment of synaptic function. Neuron. 2017 Nov 1;96(3):680-696.  PDF

Wang Y, Woehrstein JB, Donoghue N, Dai M, Avendaño MS, Schackmann RCJ, Zoeller JJ, Wang SSH, Tillberg PW, Park D, Lapan SW, Boyden ES, Brugge JS, Kaeser PS, Church GM, Agasti SS, Jungmann R, Yin P. Rapid Sequential in Situ Multiplexing with DNA Exchange Imaging in Neuronal Cells and Tissues. Nano Lett. 2017 Oct 11;17(10):6131-6139. PDF

Kawabe H, Mitkovski M, Kaeser PS, Hirrlinger J, Opazo F, Nestvogel D, Kalla S, Fejtova A, Verrier SE, Bungers SR, Cooper BH, Varoqueaux F, Wang Y, Nehring RB, Gundelfinger ED, Rosenmund C, Rizzoli SO, Südhof TC, Rhee JS, Brose N. ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones. J Cell Biol. 2017 Apr 3;216(4):1143-1161. PDF

Kaeser PS, Regehr WG: The readily releasable pool of synaptic vesicles. Curr Opin Neurobiol. 2017 Jan 16;43:63-70. PDF

 

2016 

Wang SH, Held RG, Wong MY, Liu C, Karakhanyan A, Kaeser PS: Fusion competent synaptic vesicles persist upon active zone disruption and loss of vesicle docking. Neuron 2016, 91:777-791. PDF

Held RG, Liu C, Kaeser PS: ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains. Elife. 2016 Jun 2;5. pii: e14862. doi: 10.7554/eLife.14862. PDF

 

2012 - 2015 

Liu C, Bickford LS, Held RG, Nyitrai H, Sudhof TC, Kaeser PS: The active zone protein family ELKS supports calcium influx at nerve terminals of inhibitory hippocampal neurons. J Neurosci 2014, 34:12289-12303.PMID: 25209271. PDF

Lacoste B, Comin CH, Ben-Ziv A, Kaeser PS, Xu X, Costa LF, Gu C: Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex. Neuron 2014, 83:1117-1130.PMID: 25155955. PDF

Kaeser PS, Regehr WG: Molecular mechanisms of synchronous, asynchronous and spontaneous neurotransmitter release. Annu Rev Physiol, 2014, 76: 333-363. PDF

Kaeser PS, Deng L, Fan M, Sudhof TC: RIM genes differentially contribute to organizing presynaptic release sites. PNAS 2012, 109:11830-11835. PDF

Narboux-Nême N, Evrard A, Ferezou I, Erzurumlu RS, Kaeser PS, Lainé J, Rossier J, Ropert N, Südhof TC, Gaspar P: Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex. J. Neurosci. 2012, 32:6183-6196. PDF

Haws ME, Kaeser PS, Jarvis DL, Sudhof TC, Powell CM: Region-specific deletions of RIM1 reproduce a subset of global RIM1α-/- phenotypes. Genes Brain Behav. 2012, 11:202-213. PDF

 

2011 and before 

Kaeser PS: Pushing Synaptic Vesicles over the RIM. Cellular Logistics, 2011, 3:1-5. PDF

Tsetsenis T, Younts TJ, Chiu CQ, Kaeser PS, Castillo PE, Sudhof TC: Rab3B is required for Long-term Depression of Inhibitory Synapses of the Hippocampus and for Normal Reversal Learning. PNAS 2011, 108:14300-14305. PDF

Kaeser PS, Deng L, Wang Y, Dulubova I, Liu X, Rizo J, Sudhof TC: RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell 2011, 144:282-295. PDF

Deng L, Kaeser PS, Xu W, Sudhof TC: RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13. Neuron 2011, 69:317-331. PDF

Han Y, Kaeser PS, Sudhof TC, Schneggenburger R: RIM determines Ca2+ channel density and vesicle docking at the presynaptic active zone. Neuron 2011, 69:304-316. PDF

Blundell J, Kaeser PS, Sudhof TC, Powell CM: RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia. J Neurosci 2010, 30:5326-5333. PDF

Kaeser PS, Deng L, Chavez AE, Liu X, Castillo PE, Sudhof TC: ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. Neuron 2009, 64:227-239. PDF

Kaeser PS, Kwon HB, Chiu CQ, Deng L, Castillo PE, Sudhof TC: RIM1{alpha} and RIM1{beta} Are Synthesized from Distinct Promoters of the RIM1 Gene to Mediate Differential But Overlapping Synaptic Functions. J. Neurosci. 2008, 28:13435-13447. PDF

Kaeser PS, Kwon HB, Blundell J, Chevaleyre V, Morishita W, Malenka RC, Powell CM, Castillo PE, Sudhof TC: RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning. PNAS 2008, 105:14680-14685. PDF

Chevaleyre V, Heifets BD, Kaeser PS, Sudhof TC, Castillo PE: Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha. Neuron 2007, 54:801-812. PDF

Schoch S, Mittelstaedt T, Kaeser PS, Padgett D, Feldmann N, Chevaleyre V, Castillo PE, Hammer RE, Han W, Schmitz F, Lin W, Sudhof TC: Redundant functions of RIM1alpha and RIM2alpha in Ca2+-triggered neurotransmitter release. Embo J 2006, 25:5852-5863. PDF

Lu HC, Butts DA, Kaeser PS, She WC, Janz R, Crair MC: Role of efficient neurotransmitter release in barrel map development. J Neurosci 2006, 26:2692-2703. PDF

Kaeser PS, Sudhof TC: RIM function in short- and long-term synaptic plasticity. Biochem Soc Trans 2005, 33:1345-1349. PDF

Huang YY, Zakharenko SS, Schoch S, Kaeser PS, Janz R, Sudhof TC, Siegelbaum SA, Kandel ER: Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation. PNAS 2005, 102:9365-9370. PDF

Lonart G, Schoch S, Kaeser PS, Larkin CJ, Sudhof TC, Linden DJ: Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses. Cell 2003, 115:49-60. PDF

Aguzzi A, Montrasio F, Kaeser PS: Prions: health scare and biological challenge. Nat Rev Mol Cell Biol 2001, 2:118-126. PDF

Kaeser PS, Klein MA, Schwarz P, Aguzzi A: Efficient lymphoreticular prion propagation requires PrP(c) in stromal and hematopoietic cells. J Virol 2001, 75:7097-7106. PDF

Klein MA, Kaeser PS, Schwarz P, Weyd H, Xenarios I, Zinkernagel RM, Carroll MC, Verbeek JS, Botto M, Walport MJ, Molina H, Kalinke U, Acha-Orbea H, Aguzzi A: Complement facilitates early prion pathogenesis. Nat Med 2001, 7:488-492. PDF

Aguzzi A, Klein MA, Montrasio F, Pekarik V, Brandner S, Furukawa H, Kaser P, Rockl C, Glatzel M: Prions: pathogenesis and reverse genetics. Ann N Y Acad Sci 2000, 920:140-157. PDF