2023
Chin M, Kaeser PS. The intracellular C-terminus confers compartment-specific targeting of voltage-gated Ca2+ channels. bioRxiv 2023, preprint. doi.org/10.1101/2023.12.23.573183. PDF
Emperador-Melero J, Andersen JW, Metzbower SR, Levy AD, Dharmasri PA, de Nola G, Blanpied TA, Kaeser PS. Molecular definition of distinct active zone protein machineries for Ca2+ channel clustering and synaptic vesicle priming. bioRxiv 2023, preprint. doi.org/10.1101/2023.10.27.564439. PDF
Roig Adam A, Martínez-López JA, van der Spek SJF, SynGO consortium (including Kaeser PS), Sullivan PF, Smit AB, Verhage M, Hjerling-Leffler J. Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal identity. Biol Direct 2023 May 9;18(1):22. doi: 10.1186/s13062-023-00372-y. PMID: 37161421. PDF
Lebowitz JJ, Banerjee A, Qiao C, Bunzow JR, Williams JT, Kaeser PS. Synaptotagmin-1 is a Ca2+ sensor for somatodendritic dopamine release. Cell Rep. 2023 Jan 31;42(1):111915. doi: 10.1016/j.celrep.2022.111915. Epub 2022 Dec 30. PMID: 36640316. PDF
2022
Kershberg L, Banerjee A, Kaeser PS. Protein composition of axonal dopamine release sites in the striatum. Elife. 2022 Dec 29;11:e83018. doi: 10.7554/eLife.83018. PMID: 36579890. PDF (also bioRxiv 2022.08.31.505994)
Tan C, de Nola G, Qiao C, Imig C, Born RT, Brose N, Kaeser PS. Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones. Elife. 2022 Nov 18;11:e79077. doi: 10.7554/eLife.79077. PDF (also bioRxiv 2022.04.01.486686)
Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Trubetskoy V, Pardiñas AF et al., SynGO consortium (including Kaeser PS) and other consortia, Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature. 2022 Apr;604(7906):502-508. doi: 10.1038/s41586-022-04434-5. Epub 2022 Apr 8. PMID: 35396580
Liu C, Cai X, Ritzau-Jost A, Kramer PF, Li Y, Khaliq ZM, Hallermann S, Kaeser PS. An action potential initiation mechanism in distal axons for the control of dopamine release. Science. 2022 Mar 25;375(6587):1378-1385. doi: 10.1126/science.abn0532. Epub 2022 Mar 24. PubMed PMID: 35324301. PDF. Link for full access to the paper
Tan C, Wang SSH, De Nola G, Kaeser PS. Rebuilding Essential Active Zone Functions within a Synapse. Neuron 2022 May 4;110(9):1498-1515.e8. doi: 10.1016/j.neuron.2022.01.026. Epub 2022 Feb 16. PMID: 35176221. PDF (also bioRxiv 2021.11.21.469466)
Banerjee A, Imig C, Balakrishnan K, Kershberg L, Lipstein N, Uronen R-L, Wang J, Cai X, Benseler F, Rhee JS, Cooper BH, Liu C, Wojcik SM, Brose N, Kaeser PS. Molecular and functional architecture of striatal dopamine release sites. Neuron. 2022 Jan 19;110(2):248-265.e9. doi: 10.1016/j.neuron.2021.10.028. Epub 2021 Nov 11. PMID: 34767769. PDF (also bioRxiv 2020.11.25.398255)
2021
Wang CC, Weyrer C, Fioravante D, Kaeser PS, Regehr WG. Presynaptic Short-Term Plasticity Persists in the Absence of PKC Phosphorylation of Munc18-1. J Neurosci. 2021 Sep 1;41(35):7329-7339. doi: 10.1523/JNEUROSCI.0347-21.2021. Epub 2021 Jul 21. PMID: 34031393. PDF (also bioRxiv 2021.02.14.431144)
Emperador-Melero J, Wong MY, Wang SSH, De Nola G, Kirchhausen T, and Kaeser PS. PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure. Nature Communications. 2021 May 24. doi: 10.1038/s41467-021-23116-w. PDF (also bioRxiv 2020.10.28.357574)
Liu C, Goel P, Kaeser PS. Spatial and temporal scales of dopamine transmission. Nat Rev Neurosci. 2021 Jun;22(6):345-358. doi: 10.1038/s41583-021-00455-7. Epub 2021 Apr 9. PMID: 33837376. PDF
Emperador-Melero J, De Nola G, and Kaeser PS. Intact synapse structure and function after combined knockout of PTPδ, PTPσ and LAR. Elife. 2021 Mar 3;10:e66638. doi: 10.7554/eLife.66638. PDF (also bioRxiv 2021.01.17.427005)
2020
Held RG, Liu C, Ma K, Ramsey AM, Tarr TB, De Nola G, Wang SSH, Wang J, van den Maagdenburg AMJM, Schneider T, Sun J, Blanpied TA, Kaeser PS. Synapse and active zone assembly in the absence of presynaptic Ca2+ channels and Ca2+ entry. Neuron 2020, Aug 19;107(4):667-683.e9. doi: 10.1016/j.neuron.2020.05.032. Epub 2020 Jun 16. PMID: 32616470. PDF
Nyitrai H, Wang SSH, Kaeser PS. ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals. Cell Rep 2020 Jun 9;31(10):107712. doi: 10.1016/j.celrep.2020.107712. PMID: 32521280. PDF
Banerjee A, Lee J, Nemcova P, Liu C, Kaeser PS. Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release. Elife 2020 Jun 3;9:e58359. doi: 10.7554/eLife.58359. Online ahead of print. PMID: 32490813. PDF
Emperador-Melero J, Kaeser PS. Assembly of the presynaptic active zone. Curr Opin Neurobiol 2020 May 11;63:95-103. doi: 10.1016/j.conb.2020.03.008. Online ahead of print. PMID: 32403081. PDF
Luo L, Ambrozkiewicz MC, Benseler F, Chen C, Dumontier E, Falkner S, Furlanis E, Gomez AM, Hoshina N, Huang WH, Hutchison MA, Itoh-Maruoka Y, Lavery LA, Li W, Maruo T, Motohashi J, Pai EL, Pelkey KA, Pereira A, Philips T, Sinclair JL, Stogsdill JA, Traunmüller L, Wang J, Wortel J, You W, Abumaria N, Beier KT, Brose N, Burgess HA, Cepko CL, Cloutier JF, Eroglu C, Goebbels S, Kaeser PS, Kay JN, Lu W, Luo L, Mandai K, McBain CJ, Nave KA, Prado MAM, Prado VF, Rothstein J, Rubenstein JLR, Saher G, Sakimura K, Sanes JR, Scheiffele P, Takai Y, Umemori H, Verhage M, Yuzaki M, Zoghbi HY, Kawabe H, Craig AM. Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. Neuron. 2020 Apr 8;106(1):37-65.e5. doi: 10.1016/j.neuron.2020.01.008. PDF
2019
Liu C, Kaeser PS. Nanoscale Location Matters: Emerging Principles of Ca2+ Channel Organization at the Presynaptic Active Zone. Neuron. 2019 Nov 20;104(4):627-629. doi:10.1016/j.neuron.2019.10.015. PDF.
Persoon CM, Hoogstraaten RI, Nassal JP, van Weering JRT, Kaeser PS, Toonen RF, Verhage M. The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators. Neuron. 2019 Oct 11. pii: S0896-6273(19)30788-3. doi: 10.1016/j.neuron.2019.09.015. PDF
Tyssowski KM, Letai KC, Rendall SD, Tan C, Nizhnik A, Kaeser PS, Gray JM. Firing rate homeostasis can occur in the absence of neuronal activity-regulated transcription. J Neurosci. 2019 Oct 31. pii: 1108-19. doi: 10.1523/JNEUROSCI.1108-19.2019. PDF
Robinson BG, Cai X, Wang J, Bunzow JR, Williams JT, Kaeser PS. RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain. Elife. 2019 Sep 5;8. pii: e47972. doi: 10.7554/eLife.47972. PMID: 31486769. PDF
Saka SK, Wang Y, Kishi JY, Zhu A, Zeng Y, Xie W, Kirli K, Yapp C, Cicconet M, Beliveau BJ, Lapan SW, Yin S, Lin M, Boyden ES, Kaeser PS, Pihan G, Church GM, Yin P. Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues. Nat Biotechnol. 2019 Sep;37(9):1080-1090. PMID: 31427819. PDF (also bioRxiv 507566; doi: https://doi.org/10.1101/507566)
Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Cornelisse LN, Farrell RJ, Goldschmidt HL, Howrigan DP, Hussain NK, Imig C, de Jong APH, Jung H, Kohansalnodehi M, Kramarz B, Lipstein N, Lovering RC, MacGillavry H, Mariano V, Mi H, Ninov M, Osumi-Sutherland D, Pielot R, Smalla KH, Tang H, Tashman K, Toonen RFG, Verpelli C, Reig-Viader R, Watanabe K, van Weering J, Achsel T, Ashrafi G, Asi N, Brown TC, De Camilli P, Feuermann M, Foulger RE, Gaudet P, Joglekar A, Kanellopoulos A, Malenka R, Nicoll RA, Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, Tilgner HU, Bagni C, Bayés À, Biederer T, Brose N, Chua JJE, Dieterich DC, Gundelfinger ED, Hoogenraad C, Huganir RL, Jahn R, Kaeser PS, Kim E, Kreutz MR, McPherson PS, Neale BM, O'Connor V, Posthuma D, Ryan TA, Sala C, Feng G, Hyman SE, Thomas PD, Smit AB, Verhage M. SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron. 2019 Jul 17;103(2):217-234.e4. PDF
Emperador-Melero J, Kaeser PS. Liquid Active Zones for Controlling the Phases of Synaptic Transmission. Mol Cell. 2019 Mar 7;73(5):859-860. PDF
Liu C, Kaeser PS. Mechanisms and regulation of dopamine release. Current Opinion in Neurobiology. 2019 Aug;57:46-53. PDF
2018
Wang SSH, Kaeser PS. A Presynaptic Liquid Phase Unlocks the Vesicle Cluster. Trends Neurosci. 2018 Nov;41(11):772-774. PDF
deJong APH, Roggero CM, Ho MR, Wong MY, Brautigam CA, Rizo J, Kaeser PS. RIM C2B domains target presynaptic active zone functions to PIP2-containing membranes. Neuron. 2018 Apr 18;98(2):335-349.e7. doi: 10.1016/j.neuron.2018.03.011. Epub 2018 Mar 29. PMID: 29606581 PDF
Held RH, Kaeser PS. ELKS active zone proteins as multitasking scaffolds for secretion. Open Biol. 2018 Feb;8(2). pii: 170258. doi: 10.1098/rsob.170258. Review. PMID: 29491150 PDF
Wong MY, Liu C, Wang SH, Roquas A, Fowler S, Kaeser PS. Liprin-alpha3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses. PNAS. 2018 Feb 27;115(9):2234-2239. doi: 10.1073/pnas.1719012115. Epub 2018 Feb 8. PMID: 29439199. PDF
Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser PS. Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites. Cell. 2018 Feb 8;172(4):706-718.e15. PDF
2017
Biederer TB, Kaeser PS, Blanpied TA: Transcellular nanoscale alignment of synaptic function. Neuron. 2017 Nov 1;96(3):680-696. PDF
Wang Y, Woehrstein JB, Donoghue N, Dai M, Avendaño MS, Schackmann RCJ, Zoeller JJ, Wang SSH, Tillberg PW, Park D, Lapan SW, Boyden ES, Brugge JS, Kaeser PS, Church GM, Agasti SS, Jungmann R, Yin P. Rapid Sequential in Situ Multiplexing with DNA Exchange Imaging in Neuronal Cells and Tissues. Nano Lett. 2017 Oct 11;17(10):6131-6139. PDF (also bioRxiv 112227; doi: https://doi.org/10.1101/112227)
Kawabe H, Mitkovski M, Kaeser PS, Hirrlinger J, Opazo F, Nestvogel D, Kalla S, Fejtova A, Verrier SE, Bungers SR, Cooper BH, Varoqueaux F, Wang Y, Nehring RB, Gundelfinger ED, Rosenmund C, Rizzoli SO, Südhof TC, Rhee JS, Brose N. ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones. J Cell Biol. 2017 Apr 3;216(4):1143-1161. PDF
Kaeser PS, Regehr WG: The readily releasable pool of synaptic vesicles. Curr Opin Neurobiol. 2017 Jan 16;43:63-70. PDF
2016
Wang SH, Held RG, Wong MY, Liu C, Karakhanyan A, Kaeser PS: Fusion competent synaptic vesicles persist upon active zone disruption and loss of vesicle docking. Neuron 2016, 91:777-791. PDF
Held RG, Liu C, Kaeser PS: ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains. Elife. 2016 Jun 2;5. pii: e14862. doi: 10.7554/eLife.14862. PDF
2012 - 2015
Liu C, Bickford LS, Held RG, Nyitrai H, Sudhof TC, Kaeser PS: The active zone protein family ELKS supports calcium influx at nerve terminals of inhibitory hippocampal neurons. J Neurosci 2014, 34:12289-12303.PMID: 25209271. PDF
Lacoste B, Comin CH, Ben-Ziv A, Kaeser PS, Xu X, Costa LF, Gu C: Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex. Neuron 2014, 83:1117-1130.PMID: 25155955. PDF
Kaeser PS, Regehr WG: Molecular mechanisms of synchronous, asynchronous and spontaneous neurotransmitter release. Annu Rev Physiol, 2014, 76: 333-363. PDF
Kaeser PS, Deng L, Fan M, Sudhof TC: RIM genes differentially contribute to organizing presynaptic release sites. PNAS 2012, 109:11830-11835. PDF
Narboux-Nême N, Evrard A, Ferezou I, Erzurumlu RS, Kaeser PS, Lainé J, Rossier J, Ropert N, Südhof TC, Gaspar P: Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex. J. Neurosci. 2012, 32:6183-6196. PDF
Haws ME, Kaeser PS, Jarvis DL, Sudhof TC, Powell CM: Region-specific deletions of RIM1 reproduce a subset of global RIM1α-/- phenotypes. Genes Brain Behav. 2012, 11:202-213. PDF
2011 and before
Kaeser PS: Pushing Synaptic Vesicles over the RIM. Cellular Logistics, 2011, 3:1-5. PDF
Tsetsenis T, Younts TJ, Chiu CQ, Kaeser PS, Castillo PE, Sudhof TC: Rab3B is required for Long-term Depression of Inhibitory Synapses of the Hippocampus and for Normal Reversal Learning. PNAS 2011, 108:14300-14305. PDF
Kaeser PS, Deng L, Wang Y, Dulubova I, Liu X, Rizo J, Sudhof TC: RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell 2011, 144:282-295. PDF
Deng L, Kaeser PS, Xu W, Sudhof TC: RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13. Neuron 2011, 69:317-331. PDF
Han Y, Kaeser PS, Sudhof TC, Schneggenburger R: RIM determines Ca2+ channel density and vesicle docking at the presynaptic active zone. Neuron 2011, 69:304-316. PDF
Blundell J, Kaeser PS, Sudhof TC, Powell CM: RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia. J Neurosci 2010, 30:5326-5333. PDF
Kaeser PS, Deng L, Chavez AE, Liu X, Castillo PE, Sudhof TC: ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. Neuron 2009, 64:227-239. PDF
Kaeser PS, Kwon HB, Chiu CQ, Deng L, Castillo PE, Sudhof TC: RIM1{alpha} and RIM1{beta} Are Synthesized from Distinct Promoters of the RIM1 Gene to Mediate Differential But Overlapping Synaptic Functions. J. Neurosci. 2008, 28:13435-13447. PDF
Kaeser PS, Kwon HB, Blundell J, Chevaleyre V, Morishita W, Malenka RC, Powell CM, Castillo PE, Sudhof TC: RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning. PNAS 2008, 105:14680-14685. PDF
Chevaleyre V, Heifets BD, Kaeser PS, Sudhof TC, Castillo PE: Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha. Neuron 2007, 54:801-812. PDF
Schoch S, Mittelstaedt T, Kaeser PS, Padgett D, Feldmann N, Chevaleyre V, Castillo PE, Hammer RE, Han W, Schmitz F, Lin W, Sudhof TC: Redundant functions of RIM1alpha and RIM2alpha in Ca2+-triggered neurotransmitter release. Embo J 2006, 25:5852-5863. PDF
Lu HC, Butts DA, Kaeser PS, She WC, Janz R, Crair MC: Role of efficient neurotransmitter release in barrel map development. J Neurosci 2006, 26:2692-2703. PDF
Kaeser PS, Sudhof TC: RIM function in short- and long-term synaptic plasticity. Biochem Soc Trans 2005, 33:1345-1349. PDF
Huang YY, Zakharenko SS, Schoch S, Kaeser PS, Janz R, Sudhof TC, Siegelbaum SA, Kandel ER: Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation. PNAS 2005, 102:9365-9370. PDF
Lonart G, Schoch S, Kaeser PS, Larkin CJ, Sudhof TC, Linden DJ: Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses. Cell 2003, 115:49-60. PDF
Aguzzi A, Montrasio F, Kaeser PS: Prions: health scare and biological challenge. Nat Rev Mol Cell Biol 2001, 2:118-126. PDF
Kaeser PS, Klein MA, Schwarz P, Aguzzi A: Efficient lymphoreticular prion propagation requires PrP(c) in stromal and hematopoietic cells. J Virol 2001, 75:7097-7106. PDF
Klein MA, Kaeser PS, Schwarz P, Weyd H, Xenarios I, Zinkernagel RM, Carroll MC, Verbeek JS, Botto M, Walport MJ, Molina H, Kalinke U, Acha-Orbea H, Aguzzi A: Complement facilitates early prion pathogenesis. Nat Med 2001, 7:488-492. PDF
Aguzzi A, Klein MA, Montrasio F, Pekarik V, Brandner S, Furukawa H, Kaser P, Rockl C, Glatzel M: Prions: pathogenesis and reverse genetics. Ann N Y Acad Sci 2000, 920:140-157. PDF